Two in each group (13.3%) needed re-administration of intravenous diazepam due to persistent agitation. The most common symptoms/signs were agitation (29 96.7%), mydriatic pupils (26 86.7%), and tachycardia (20 66.6%). The source of poisoning was methamphetamine exposure from oral ingestion in 23 (76.7%) and passive inhalation in 7 (23.3%) patients.
The median age (range) was 15 (6-144) months. In a single-center clinical trial, intravenous diazepam (0.2 mg/Kg) was initially administered to all methamphetamine-poisoned pediatric patients to control their agitation, followed by a single dose of oral clonazepam (0.05 mg/Kg n = 15) or oral lorazepam (0.05 mg/Kg n = 15) to prevent relapse of toxicity. To evaluate the efficacy of oral clonazepam versus oral lorazepam following initial parenteral benzodiazepine administration to control methamphetamine-induced agitation in children.
0 kommentar(er)
